I currently run pyTiVo X on a (slow) Mac OS X machine. It reads movie files off my Drobo-FS and serves them up to my TiVo. Most of my movie files are in M4V or MP4 format, encoded in such a way that the TiVo can read them natively, thus requiring no CPU time on the computer to transcode on the fly.
This got me to thinking that it should be possible to get pyTiVo (for Linux) running on Drobo-FS. Has anyone attempted this or have any thoughts on the process?