I have a 1st gen drobo running 4 (four) 1.5 tb wd caviar drives on a 3-4 yr old hp running vista. I have a large collection (over 100K tracks) of music mostly ripped in apple lossless.
itunes takes a great long time to launch when the drobo is connected, but not so much when it’s not. i have an airport express that drops for a second or two about every minute. i have spent hours on the phone with apple tech support, but they have no solution.