I have a late 2013 iMac running Sierra and a gen 2 Drobo w/ firewire 800 & USB.
I am trying to use 1 of 2 configurations:
1: I have an Apple FW800-Thunderbolt adaptor. When I use this, the Drobo doesn’t always show up after a reboot. Plus, the finder will sometimes hang.
2: Connect to a USB port. The iMac has USB 3 which should be backward compatible to USB 2 which is what the Drobo uses. This seems slightly more stable, but the drive takes upwards of 10-minutes to mount after a reboot… When it mounts. There are still times when I have to unplug the Drobo (the power, not the USB) in order for it to mount. Also Finder still hangs, though not as frequently as w/ the Thunderbolt option above.
I’ve seen where the dashboard sees the drive, but Disk Utility doesn’t.
Meanwhile, on my slowly dying 2007 Mac Mini, I connect with a FW800-FW400 cable and it’s rock solid.